Subacute sclerosing panencephalitis (SSPE) is a slowly progressing, chronic persistent fatal central nervous system disease, involving gray and white matter, especially white matter caused by measles virus that affecting gray and young adult. 45
to
68%
of affected individuals had measles before the age of 2. Current knowledge of the pathogenesis of SSPE involves mutation of the measles virus , resulting in lack of production of the M(Matrix)-protein. No therapeutic maneuvour gas been proven
conclusively to be of value. But recently intraventricular alpha-interferon (α-IFN) injection combed with oral inosiplex increase the length of survival and may bring remission or stabilization in SSPE. We report a case of SSPE which was
diagnosed
by
history, clinical manifestation, typical EEG findings, high titer of measles antibodies in cerebrospinal fluid and serum by hemagglutinin inhibition method. We tried intraventricular α-IF injection via Ommaya reservoir and oral inosiplex.
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